Optogenetic control of apical constriction induces synthetic morphogenesis in mammalian tissues

Autor: Guillermo Martínez-Ara, Núria Taberner, Mami Takayama, Elissavet Sandaltzopoulou, Casandra E. Villava, Miquel Bosch-Padrós, Nozomu Takata, Xavier Trepat, Mototsugu Eiraku, Miki Ebisuya
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-33115-0
Popis: Apical constriction is a force-generating process required during embryonic development; there is a lack of tools to manipulate 3D shapes of mammalian tissues. Here the authors report the optogenetic method, OptoShroom3, to achieve fast spatiotemporal control of apical constriction in mammalian epithelia.
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