| Autor: |
I. K. Namazova, L. M. Akhmedova, S. R. Medjidova |
| Jazyk: |
ruština |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Oftalʹmologiâ, Vol 9, Iss 3, Pp 46-51 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1816-5095 |
| Popis: |
Purpose: Investigation of the parameters of innate immunity in senile group patients with eye injury.Methods: Standard ophthalmologic and immunologic study of 12 patients aged 63±11 with eye injury complicated by inflamma- tion. Immunological study of peripheral blood, tear and conjunctival scraping from the injured eye and the binate eye was carried out on 1-3 days after the injury. the parameters of innate local immunity was determined in the result of immune-cytological study of the conjunctival scraping by assessing phagocytosis of neutrophils and index of neutrophils/lymphocytes (INL), immunofluorescent counting of NK-cells CD56+ (panel of monoclonal antibodies of company «Sorbent» Ltd., Russia). the concentration of transferrin (a set of «Human» Company, Germany) in the blood and lacrimal fluid was assayed by the biochemical analyzer (Bioscreen MS-500). the results obtained were processed by the method of variational statistics.Results: As a result of the conducted studies there has been detected a decrease in the amount of transferrin both in blood and lacrimal fluid by almost 2 times (p Conclusion: In the senile group patients with an eye injury there is an activation of nonspecific defense factors, mainly, on the local level: neutrophilic infiltration of the mucosa of the conjunctiva, increase in INL on the average to 4.9, increase in the number of NK-cells. the sharp decrease in the concentration of transferrin in the systemic and local level can serve as an additional diagnostic criterion for inflammatory activity in eye trauma. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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