Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease
| Autor: | Lucas Malta Almeida, Lenora Gandolfi, Riccardo Pratesi, Rosa Harumi Uenishi, Fernanda Coutinho de Almeida, Nicole Selleski, Yanna Karla de Medeiros Nóbrega |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Autoimmune Diseases, Vol 2016 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2090-0422 2090-0430 |
| DOI: | 10.1155/2016/5409653 |
| Popis: | Background. Celiac disease (CD) is a genetically determined immune-mediated disorder in which gluten immunogenic peptides are presented to CD4 T cells by HLA-DQ2.5, DQ8, DQ2.2, and their combinations. Our aim is to establish a risk gradient for celiac disease based on HLA-DQ profile in a brazilian representative population and the relevance of DQ2.2 in celiac disease development. Materials and Methods. 237 celiac patients and 237 controls (both groups with 164 females and 73 males) were included. All samples were tested for the presence of predisposing HLA-DQ alleles using the PCR-SSP method. Results were considered significant when p |
| Databáze: | Directory of Open Access Journals |
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