| Autor: |
Chi-Long Chen, Chun-Yi Chiang, Kuang-Wen Liao, Shu-Yi Ho, Yi-Fang Chang, Ken-Hong Lim, Ruey-Kuen Hsieh, Yu-Ling Lin, Ying-Wen Su |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
International Journal of Gerontology, Vol 11, Iss 1, Pp 22-26 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
1873-9598 |
| DOI: |
10.1016/j.ijge.2016.04.003 |
| Popis: |
Background: Evidence indicates apoptosis deregulation is associated with aging. We correlated expression of cIAP-2, a member of the inhibitor of apoptosis protein family, with survival and age in patients with resected squamous cell carcinoma of head and neck (SCCHN). Methods: Immunohistochemical (IHC) staining for cIAP-2 and other markers were performed using tissue microarrays from 103 resected SCCHN patients. Expression was grouped according to IHC scores (0–3) and statistical association with clinical–pathological factors was determined. Results: High expression of cIAP-2 was found to be increased in patients aged 60 or greater. High expression of cIAP-2 and an age ≥60 were significantly associated with worse survival in univariate analysis, but only an age ≥60, and not cIAP-2 expression, was prognostic in multivariate analysis. Conclusion: High expression of cIAP-2 was found more frequently in elderly SCCHN patients but was not independently associated with survival after adjusting other clinical–pathologic factors. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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