Impact of suboptimal donor to suboptimal recipient kidney transplant on delayed graft function and outcome

Autor: Federica Bocchi, Guido Beldi, Christian Kuhn, Federico Storni, Natalie Müller, Daniel Sidler
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Frontiers in Transplantation, Vol 2 (2023)
Druh dokumentu: article
ISSN: 2813-2440
DOI: 10.3389/frtra.2023.1240155
Popis: IntroductionThe demographics of donor and recipient candidates for kidney transplantation (KT) have substantially changed. Recipients tend to be older and polymorbid and KT to suboptimal recipients is associated with delayed graft function (DGF), prolonged hospitalization, inferior long-term allograft function, and poorer patient survival. In parallel, donors are also older, suffer from several comorbidities, and donations coming from circulatory death (DCD) predominate, which in turn leads to early and late complications. However, it is unclear how donor and recipient risk factors interact.MethodsIn this retrospective cohort study, we assess the impact of a KT from suboptimal donors to suboptimal recipients. We focused on: 1) DGF; 2) hospital stay and number of dialysis days after KT and 3) allograft function at 12 months.Results and discussionAmong the 369 KT included, the overall DGF rate was 25% (n = 92) and median time from reperfusion to DGF resolution was 7.8 days (IQR: 3.0–13.8 days). Overall, patients received four dialysis sessions (IQR: 2–8). The combination of pre-KT anuria (
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