Alpha-synuclein alters the faecal viromes of rats in a gut-initiated model of Parkinson’s disease

Autor: Stephen R. Stockdale, Lorraine A. Draper, Sarah M. O’Donovan, Wiley Barton, Orla O’Sullivan, Laura A. Volpicelli-Daley, Aideen M. Sullivan, Cora O’Neill, Colin Hill
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-021-02666-1
Popis: Stockdale et al. assess longitudinal faecal virome changes in a rat model of Parkinson’s Disease (PD) in which either monomeric or preformed fibrils (PFF) of α-synuclein were administered directly into their enteric nervous system. They demonstrate that virome alterations are potentially reactive to host α-synuclein changes that are associated with PD development.
Databáze: Directory of Open Access Journals
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