Independent effects of sex and stress on fructose‐induced salt‐sensitive hypertension

Autor:	Autumn Brostek, Nancy J. Hong, Ronghao Zhang, Beau R. Forester, Lauren E. Barmore, Lindsey Kaydo, Nicholas Kluge, Corey Smith, Jeffrey L. Garvin, Agustin Gonzalez‐Vicente
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	blood pressure norepinephrine renal sympathetic nerve salt‐sensitive hypertension Physiology QP1-981
Zdroj:	Physiological Reports, Vol 10, Iss 19, Pp n/a-n/a (2022)
Druh dokumentu:	article
ISSN:	2051-817X
DOI:	10.14814/phy2.15489
Popis:	Abstract Proximal tubule fructose metabolism is key to fructose‐induced hypertension, but the roles of sex and stress are unclear. We hypothesized that females are resistant to the salt‐sensitive hypertension caused by low amounts of dietary fructose compared to males and that the magnitude of the increase in blood pressure (BP) depends, in part, on amplification of the stress response of renal sympathetic nerves. We measured systolic BP (SBP) in rats fed high salt with either no sugar (HS), 20% glucose (GHS) or 20% fructose (FHS) in the drinking water for 7–8 days. FHS increased SBP in both males (Δ22 ± 9 mmHg; p
Databáze:	Directory of Open Access Journals
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