Altered resting brain connectivity in persistent cancer related fatigue
| Autor: | Johnson P. Hampson, Suzanna M. Zick, Tohfa Khabir, Benjamin D. Wright, Richard E. Harris |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Persistent cancer related fatigue (PCRF)
Breast cancer survivors Functional connectivity magnetic resonance imaging (fcMRI) Independent component analysis (ICA) Default mode network (DMN) Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429 |
| Zdroj: | NeuroImage: Clinical, Vol 8, Iss C, Pp 305-313 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2015.04.022 |
| Popis: | There is an estimated 3 million women in the US living as breast cancer survivors and persistent cancer related fatigue (PCRF) disrupts the lives of an estimated 30% of these women. PCRF is associated with decreased quality of life, decreased sleep quality, impaired cognition and depression. The mechanisms of cancer related fatigue are not well understood; however, preliminary findings indicate dysfunctional activity in the brain as a potential factor. Here we investigate the relationship between PCRF on intrinsic resting state connectivity in this population. Twenty-three age matched breast cancer survivors (15 fatigued and 8 non-fatigued) who completed all cancer-related treatments at least 12 weeks prior to the study, were recruited to undergo functional connectivity magnetic resonance imaging (fcMRI). Intrinsic resting state networks were examined with both seed based and independent component analysis methods. Comparisons of brain connectivity patterns between groups as well as correlations with self-reported fatigue symptoms were performed. Fatigued patients displayed greater left inferior parietal lobule to superior frontal gyrus connectivity as compared to non-fatigued patients (P |
| Databáze: | Directory of Open Access Journals |
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