In-depth analysis of lupeol: delving into the diverse pharmacological profile
| Autor: | Aminah Dalimunthe, Mega Carensia Gunawan, Zahirah Dhiya Utari, Muhammad Riza Dinata, Princella Halim, Nathasya Estherina S. Pakpahan, Alex Insandus Sitohang, M. Andriansyah Sukarno, Yuandani, Yahdiana Harahap, Erna Prawita Setyowati, Moon Nyeo Park, Syaratul Dalina Yusoff, Satirah Zainalabidin, Arya Tjipta Prananda, Mohd Kaisan Mahadi, Bonglee Kim, Urip Harahap, Rony Abdi Syahputra |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Frontiers in Pharmacology, Vol 15 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1663-9812 05681723 |
| DOI: | 10.3389/fphar.2024.1461478 |
| Popis: | Lupeol, a naturally occurring lupane-type pentacyclic triterpenoid, is widely distributed in various edible vegetables, fruits, and medicinal plants. Notably, it is found in high concentrations in plants like Tamarindus indica, Allanblackia monticola, and Emblica officinalis, among others. Quantitative studies have highlighted its presence in Elm bark, Olive fruit, Aloe leaf, Ginseng oil, Mango pulp, and Japanese Pear bark. This compound is synthesized from squalene through the mevalonate pathway and can also be synthetically produced in the lab, addressing challenges in natural product synthesis. Over the past four decades, extensive research has demonstrated lupeol’s multifaceted pharmacological properties, including anti-inflammatory, antioxidant, anticancer, and antibacterial effects. Despite its significant therapeutic potential, clinical applications of lupeol have been limited by its poor water solubility and bioavailability. Recent advancements have focused on nano-based delivery systems to enhance its bioavailability, and the development of various lupeol derivatives has further amplified its bioactivity. This review provides a comprehensive overview of the latest advancements in understanding the pharmacological benefits of lupeol. It also discusses innovative strategies to improve its bioavailability, thereby enhancing its clinical efficacy. The aim is to consolidate current knowledge and stimulate further research into the therapeutic potential of lupeol and its derivatives. |
| Databáze: | Directory of Open Access Journals |
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