Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization

Autor: Ruili Huang, Menghang Xia, Srilatha Sakamuru, Jinghua Zhao, Sampada A. Shahane, Matias Attene-Ramos, Tongan Zhao, Christopher P. Austin, Anton Simeonov
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms10425
Popis: Large-scale in vitro assays may reduce the number of toxicological tests carried out in animals. Here, Huang et al. report a large dataset containing results of in vitrotests of approximately 10,000 chemicals, and use these data to create models that can potentially predict toxicity in humans.
Databáze: Directory of Open Access Journals