Changes in the clinical course and prognosis of ulcerative colitis in Chinese populations: a retrospective cohort study

Autor: Xinyu Liu, Qingfan Yang, Na Diao, Jian Tang, Zicheng Huang, Xiang Gao, Kang Chao
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Intestinal Research, Vol 22, Iss 3, Pp 357-368 (2024)
Druh dokumentu: article
ISSN: 1598-9100
2288-1956
DOI: 10.5217/ir.2023.00106
Popis: Background/Aims Data on the natural course of Chinese patients with ulcerative colitis (UC) was lacking. This study aimed to evaluate the natural history and prognosis of patients with UC in the past 15 years in China. Methods This cohort study included patients with UC in a tertiary hospital in southern China from 2007 to 2021 (cohort I: 2007–2011, cohort II: 2012–2016, cohort III: 2017–2021). Patients’ clinical characteristics and natural history were analyzed retrospectively. Results Of 1,139 included patients, 683 patients presented with proctitis or left-sided colitis at diagnosis and 38.5% of them (263/683) developed proximal disease extension. Fifty-eight percent of patients experienced relapse, chronic continuous and intermittent active course. Five patients (0.4%) developed colorectal tumors/dysplasia. The overall surgery rate was 8.6%, and the rates were 14.2%, 7.8%, and 8.0% in the 3 cohorts, respectively (P=0.059). Average time from diagnosis to surgery decreased from cohorts I to III (144 months vs. 36 months, P
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