The potential epidemic threat of Ebola virus and the development of a preventive vaccine

Autor: Hong-Qing Zhang, Qiu-Yan Zhang, Zhi-Ming Yuan, Bo Zhang
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Biosafety and Biosecurity, Vol 5, Iss 2, Pp 67-78 (2023)
Druh dokumentu: article
ISSN: 2588-9338
DOI: 10.1016/j.jobb.2023.05.001
Popis: Ebola virus (EBOV) is classified as a category A pathogen as it causes viral hemorrhagic fever, one of the most-deadly virus-related diseases. Since its discovery in 1976, EBOV has caused a number of global public health incidents, which have posed a serious threat to both humans and non-human primates. Thus, numerous preventive vaccine studies are underway, including research on inactivated vaccines, DNA vaccines, subunit vaccines, virus-like particles, Venezuelan equine encephalitis virus replicon particles, and several viral vector vaccines. The vesicular stomatitis virus-based vaccine Ervebo was recently approved by the Food and Drug Administration and the European Union, and several other vaccines have also been proven to confer potent protection in non-human primates against EBOV lethal challenge. This review provides a brief background of EBOV, with a focus on the epidemiology, available animal models, and advances in preventive approaches for EBOV infection.
Databáze: Directory of Open Access Journals