Hyperhomocysteinemia exacerbates ischemia-reperfusion injury-induced acute kidney injury by mediating oxidative stress, DNA damage, JNK pathway, and apoptosis

Autor: Zhang Mei, Yuan Jing, Dong Rong, Da Jingjing, Li Qian, Hu Ying, Yu Fangfang, Ran Yan, Zha Yan, Long Yanjun
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Open Life Sciences, Vol 16, Iss 1, Pp 537-543 (2021)
Druh dokumentu: article
ISSN: 2391-5412
DOI: 10.1515/biol-2021-0054
Popis: Hyperhomocysteinemia (HHcy) plays an important role in the progression of many kidney diseases; however, the relationship between HHcy and ischemia-reperfusion injury (IRI)-induced acute kidney injury (IRI-induced AKI) is far from clear. In this study, we try to investigate the effect and possible mechanisms of HHcy on IRI-induced AKI.
Databáze: Directory of Open Access Journals