| Autor: |
Ling Leng, Jie Ma, Pei-Pei Zhang, Si-Chi Xu, Xiao Li, Ye Jin, Jun Cai, Rui Tang, Lei Zhao, Zhi-Cheng He, Man-Sheng Li, Hui Zhang, Liang-Rui Zhou, Zhi-Hong Wu, Tian-Ran Li, Yun-Ping Zhu, Yu-Jie Wang, Hai-Bo Wu, Yi-Fang Ping, Xiao-Hong Yao, Chu-Hong Zhu, Hai-Tao Guo, Le-Yong Tan, Zhi-Yong Liang, Xiu-Wu Bian, Shu-Yang Zhang |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Cell Reports, Vol 39, Iss 11, Pp 110955- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2211-1247 |
| DOI: |
10.1016/j.celrep.2022.110955 |
| Popis: |
Summary: Direct myocardial and vascular injuries due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-driven inflammation is the leading cause of acute cardiac injury associated with coronavirus disease 2019 (COVID-19). However, in-depth knowledge of the injury characteristics of the heart affected by inflammation is lacking. In this study, using a quantitative spatial proteomics strategy that combines comparative anatomy, laser-capture microdissection, and histological examination, we establish a region-resolved proteome map of the myocardia and microvessels with obvious inflammatory cells from hearts of patients with COVID-19. A series of molecular dysfunctions of myocardia and microvessels is observed in different cardiac regions. The myocardia and microvessels of the left atrial are the most susceptible to virus infection and inflammatory storm, suggesting more attention should be paid to the lesion and treatment of these two parts. These results can guide in improving clinical treatments for cardiovascular diseases associated with COVID-19. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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