Grafting chlorogenic acid enhanced the antioxidant activity of curdlan oligosaccharides and modulated gut microbiota

Autor: Huan Li, Wenjiang He, Saiqing Xu, Rongrong Wang, Shuai Ge, Haishan Xu, Yang Shan, Shenghua Ding
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Food Chemistry: X, Vol 21, Iss , Pp 101075- (2024)
Druh dokumentu: article
ISSN: 2590-1575
DOI: 10.1016/j.fochx.2023.101075
Popis: In this study, the effects of grafting chlorogenic acid (CA) on the antioxidant and probiotic activities of curdlan oligosaccharides (CDOS) were investigated. CDOS with degrees of polymerization of 3–6 was first obtained by degradation of curdlan with hydrogen peroxide and then grafted with CA using a free radical-mediated method under an ultrasonication-assisted Fenton system. The thermal stability and antioxidant ability of CDOS were enhanced after grafting with CA. In vitro fermentation, supplementation of CDOS-CA stimulated the proliferation of Prevotella and Faecalibacterium while inhibiting the growth of harmful microbiota. Notably, the concentration of total short-chain fatty acids and the relative abundance of beneficial bacteria markedly increased after fermentation of CDOS-CA, indicating that CA grafting could improve the probiotic activity of CDOS. Overall, the covalent binding of CDOS and CA could enhance the antioxidant and probiotic activities of CDOS, suggesting potential improvements in gastrointestinal and colonic health.
Databáze: Directory of Open Access Journals