| Autor: |
Dana Kappel, Hugh Gifford, Amelie Brackin, Alireza Abdolrasouli, David W. Eyre, Katie Jeffery, Silke Schlenz, David M. Aanensen, Colin S. Brown, Andrew Borman, Elizabeth Johnson, Alison Holmes, Darius Armstrong-James, Matthew C. Fisher, Johanna Rhodes |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
npj Antimicrobials and Resistance, Vol 2, Iss 1, Pp 1-10 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2731-8745 |
| DOI: |
10.1038/s44259-024-00043-6 |
| Popis: |
Abstract Candida auris is a globally emerged fungal pathogen causing nosocomial invasive infections. Here, we use cutting-edge genomic approaches to elucidate the temporal and geographic epidemiology of drug-resistant C. auris within the UK. We analysed a representative sample of over 200 isolates from multiple UK hospitals to assess the number and timings of C. auris introductions and infer subsequent patterns of inter- and intra-hospital transmission of azole drug-resistant isolates. We identify at least one introduction from Clade I and two from Clade III into the UK, and observe temporal and geographical evidence for multiple transmission events of antifungal drug resistant isolates between hospitals and identified local within-hospital patient-to-patient transmission events. Our study confirms outbreaks of drug-resistant C. auris are linked and that transmission amongst patients occurs, explaining local hospital outbreaks, and demonstrating a need for improved epidemiological surveillance of C. auris to protect patients and healthcare services. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full text from SpringerLink