Shotgun metagenomic analysis of the oral microbiome in gingivitis: a nested case-control study

Autor:	Muhammed Manzoor, Jaakko Leskelä, Milla Pietiäinen, Nicolas Martinez-Majander, Eija Könönen, Teemu Niiranen, Leo Lahti, Juha Sinisalo, Jukka Putaala, Pirkko J. Pussinen, Susanna Paju
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Metagenomics oral microbiome periodontal disease chronic periodontitis saliva biomarker Infectious and parasitic diseases RC109-216 Microbiology QR1-502
Zdroj:	Journal of Oral Microbiology, Vol 16, Iss 1 (2024)
Druh dokumentu:	article
ISSN:	20002297 2000-2297
DOI:	10.1080/20002297.2024.2330867
Popis:	Background Gingivitis, i.e. inflammation of the gums, is often induced by dental plaque. However, its exact link to the oral microbiota remains unclear.Methods In a case-control study involving 120 participants, comprising 60 cases and 60 controls (mean age (SD) 36.6 (7.6) years; 50% males), nested within a prospective multicentre cohort study, we examined the oral microbiome composition of gingivitis patients and their controls using shotgun metagenomic sequencing of saliva samples. Participants underwent clinical and radiographic oral health examinations, including bleeding on probing (BOP), at six tooth sites. BOP ≥33% was considered ‘generalized gingivitis/initial periodontitis’(GG/IP), and BOP
Databáze:	Directory of Open Access Journals
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