| Autor: |
Nahed S. Alharthi, Fahad M. Aldakheel, Abdulkarim S. Binshaya |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Bioinorganic Chemistry and Applications, Vol 2022 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1687-479X |
| DOI: |
10.1155/2022/1401995 |
| Popis: |
A critical factor in the cause and progression of Alzheimer’s disease (AD) is the growth of β-amyloid peptide (Aβ) in the brain. The mechanism of this effect is still unknown, although the effect of osthol on Aβ-induced inflammation is neuroprotective in AD and supplementation with zinc might prevent or delay the onset of dementia. In the current study, by inducing APP vector in human BE (2)-M17 cells, we established a cellular model of AD and investigated the protective effect of osthol (7-methoxy-8-3-methyl-2-butenyl-2H-1-benzopyran-2-one)-zinc oxide nanoparticles. The osthol-conjugated zinc oxide nanoparticles could significantly increase cell viability by inhibiting cell apoptosis. Osthol treatment has also prevented synaptic proteins such as postsynaptic density-95 (PSD-95), synaptophysin (SYP), and synapsin-1 from decreasing in APP-induced BE (2)-M17 cells. In addition, the expression of miR-132 was significantly upregulated by osthol by triggering the Wnt/β-catenin signaling pathway. We conclude from our observations that osthol is a potential drug for the treatment of a neurodegenerative disease, Alzheimer’s. The key reason was that by upregulating miR-132, osthol could inhibit APP expression to prevent AD from occurring. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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