Loss of MIG-6 results in endometrial progesterone resistance via ERBB2

Autor: Jung-Yoon Yoo, Tae Hoon Kim, Jung-Ho Shin, Ryan M. Marquardt, Ulrich Müller, Asgerally T. Fazleabas, Steven L. Young, Bruce A. Lessey, Ho-Geun Yoon, Jae-Wook Jeong
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-28608-x
Popis: Female subfertility is highly associated with endometriosis. Here the authors show that progesterone-induced MIG-6 is reduced in endometrium of infertile women and non-human primates with endometriosis, and in a mouse model find that Erbb2 is the key mediator of Mig-6 loss induced endometriosis-related infertility.
Databáze: Directory of Open Access Journals