In Vitro Anti-Candida Activity of Lidocaine and Nitroglycerin: Alone and Combined
| Autor: | Ana Palmeira-de-Oliveira, Ana Rita Ramos, Carlos Gaspar, Rita Palmeira-de-Oliveira, Paula Gouveia, José Martinez-de-Oliveira |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Infectious Diseases in Obstetrics and Gynecology, Vol 2012 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1064-7449 1098-0997 |
| DOI: | 10.1155/2012/727248 |
| Popis: | The aim of this work was to study the anti-Candida activity of lidocaine and nitroglycerin alone and in combination. Ten Candida strains were included, corresponding to 1 collection type strain (ATCC 10231) and 9 clinical isolates: 4 C. albicans, 2 C. glabrata, 1 C. tropicalis, 1 C. krusei, and 1 C. parapsilosis. The CLSI reference M27-A3 micromethod was used to determine the anti-Candida activity of the drugs alone; minimal inhibitory and lethal concentrations were determined. The classic checkboard technique was used to determine the activity of combined drugs. Lidocaine fungicidal effect was dosedependent. Nitroglycerin exhibited a higher effect. The drugs combination resulted in a reduction of the inhibitory concentration, corresponding to an additive effect. In conclusion, both drugs exhibited an interesting anti-Candida activity. The combination of lidocaine with nitroglycerin was shown to have an additive effect against Candida spp., predicting the interest to include, in the future, these drugs in a new delivery system for the treatment of mucocutaneous candidosis. |
| Databáze: | Directory of Open Access Journals |
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