Microglial Activation: Key Players in Sepsis-Associated Encephalopathy

Autor:	Jiyun Hu, Shucai Xie, Haisong Zhang, Xinrun Wang, Binbin Meng, Lina Zhang
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	sepsis-associated encephalopathy microglial activation M1/M2 microglial polarization cognitive impairment therapeutic strategies Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Zdroj:	Brain Sciences, Vol 13, Iss 10, p 1453 (2023)
Druh dokumentu:	article
ISSN:	2076-3425
DOI:	10.3390/brainsci13101453
Popis:	Sepsis-associated encephalopathy (SAE) is a common brain dysfunction, which results in severe cognitive and neurological sequelae and an increased mortality rate in patients with sepsis. Depending on the stimulus, microglia (resident macrophages in the brain that are involved in SAE pathology and physiology) can adopt two polarization states (M1/M2), corresponding to altered microglial morphology, gene expression, and function. We systematically described the pathogenesis, morphology, function, and phenotype of microglial activation in SAE and demonstrated that microglia are closely related to SAE occurrence and development, and concomitant cognitive impairment. Finally, some potential therapeutic approaches that can prime microglia and neuroinflammation toward the beneficial restorative microglial phenotype in SAE were outlined.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/6a93a14ce6cd4d74a7b5c61d8d56cbf1 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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