Long-term cognitive recovery following isolated bilateral infarction of the fornix presenting with amnesia

Autor: Philip MC Choi, Jennifer Bradshaw, Scott Wrigley
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMJ Neurology Open, Vol 6, Iss 1 (2024)
Druh dokumentu: article
ISSN: 2632-6140
DOI: 10.1136/bmjno-2024-000655
Popis: Introduction Isolated infarction of the fornix is a relatively rare stroke syndrome frequently associated with amnesia. The long-term cognitive outcome in cases of acute fornix infarction is poorly understood. This is largely due to the limited number of case studies that have documented cognitive outcomes beyond the acute recovery phase on quantifiable neuropsychological measures. We describe a patient who developed acute amnesia and was subsequently diagnosed on cerebral MRI with bilateral infarction in the anterior columns of the fornix.Method Comprehensive neuropsychological review was undertaken prospectively at baseline, early and late phases of recovery.Results At 9 months post-stroke, there was some reduction in the severity of memory dysfunction, but a significant anterograde amnesia persisted.Conclusion This is one of the very few cases in the literature where neuropsychological function has been comprehensively and serially examined over the first year post-isolated bilateral fornix infarction. It is concluded that amnesia can persist well beyond 6 months in these cases, with associated functional impairment in daily life.
Databáze: Directory of Open Access Journals