| Autor: |
Brunna Soares Rodrigues Costa, Erika Paula Silva Freitas, Marina Sampaio Cruz, Victor Hugo Rezende Duarte, Ananília Medeiros Gomes da Silva, Isabelle Cristina Clemente dos Santos, Jéssica Cavalcante dos Santos, Adriana Augusto Rezende, Karine Cavalcanti Maurício Sena-Evangelista, Vivian Nogueira Silbiger |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Brazilian Journal of Pharmaceutical Sciences, Vol 53, Iss 3 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2175-9790 |
| DOI: |
10.1590/s2175-97902017000317185 |
| Popis: |
ABSTRACT Chronic kidney disease (CKD) increases cardiovascular disease (CVD) risk development. However, the mechanisms of reduced kidney function with CVD risk are unclear. This study aimed to investigate the association between kidney function and Framingham risk score (FRS) in participants with traditional cardiovascular risk factors and normal estimated glomerular filtration rate (eGFR) > 60 mL/min/1.73 m² in an admixed population of Brazil. The participants were divided into three groups according to FRS: low risk group with 0% to 20%. The eGFR was calculated using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). Data from participants were collected by questionnaire, and blood and urine samples were collected to analyze biochemical markers. A total of 214 subjects aged 53±10 years old was collected. There were 77 individuals in low risk group, 59 in moderate risk group and 78 in high-risk group. Mean eGFRCKD-EPI was 89.39±15.05 mL/min/1.73 m² and 90.74±16.17 mL/min/1.73 m2 when race adjustment. The results indicated that there is an increasing the cardiovascular risk with a decreased of eGFR, conforming to a significant inverse correlation observed between eGFR and FRS with Spearman correlation (R²=-0.256, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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