Altered Serum and Cerebrospinal Fluid TNF-α, Caspase 3, and IL 1β in COVID-19 Disease
| Autor: | Mahtab Ramezani, Omidvar Rezaei, Ilad Alavi Darzam, Mohammadreza Hajiesmaeili, Mahdi Amirdosara, Leila Simani, Abbas Aliaghaei |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Caspian Journal of Internal Medicine, Vol 13, Iss Covid 19 Supplement 2, Pp 264-269 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2008-6164 2008-6172 |
| Popis: | Background: We evaluated the levels of the tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and caspase-3 in the cerebrospinal fluid (CSF) and serum of COVID-19 patients to improve our knowledge about underlying mechanisms caused by this virus in central nervous system involvement. Case Presentation: This case series study included six COVID-19 patients from March 26, 2020, to April 17, 2020, and six healthy control patients. CSF and serum levels of TNF-α, IL-1β, and caspase-3 have been assayed using monoclonal antibodies-based ELISAs. Patients with COVID-19 had significantly higher level of IL-1β, TNF-α, and caspase-3 in serum (239.16±35.73 pg/ml, 100.50±12.49 pg/ml, 3.58±0.11pg/ml, p < 0.001) and CSF (146.66±17.55 pg/ml, 63.16±14.68 pg/ml,3.22±0.03pg/ml, p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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