Hematopoietic stem cell transplantation from an infected SARS-CoV2 haploidentical donor: A case report

Autor: Xin Chen, Qiaoling Ma, Aiming Pang, Donglin Yang, Chen Liang, Qingzhen Liu, Xin Liu, Xiaohui Zheng, Erlie Jiang, Mingzhe Han, Sizhou Feng
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: IDCases, Vol 34, Iss , Pp e01913- (2023)
Druh dokumentu: article
ISSN: 2214-2509
DOI: 10.1016/j.idcr.2023.e01913
Popis: Introduction: We report a case of an adult hematopoietic stem cell donor who developed active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the donation of stem cells, the final transplantation was successfully completed without SARS-CoV-2 transmission. Case report: We report on a 34-year-old female diagnosed with acute lymphoblastic leukemia who underwent hemiploid hematopoietic stem cell transplantation (HSCT). Both patient and donor received three doses of inactivated SARS-CoV-2 vaccine before transplantation. PB-HSC was collected by the donor during the process of infection with SARS-CoV-2 (mild), and the patient did not show symptoms related to SARS-CoV-2 after transplantation. Nucleic acid and antigen were negative in regular tests. Conclusion: In the context of the current Omicron epidemic and high vaccination rate in the population, it is feasible to receive PB-HSC from infected donors even for immunocompromised patients. This also provides some references for our later donor selection.
Databáze: Directory of Open Access Journals