Fibroblasts in cancer dormancy: foe or friend?

Autor:	Li Dai, Mao Li, Wei-long Zhang, Ya-Jie Tang, Ya-ling Tang, Xin-hua Liang
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Fibroblast Cancer dormancy CAF Senescence Cancer therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Zdroj:	Cancer Cell International, Vol 21, Iss 1, Pp 1-11 (2021)
Druh dokumentu:	article
ISSN:	1475-2867
DOI:	10.1186/s12935-021-01883-2
Popis:	Abstract Cancer dormancy is defined that the residual cancer cells could enter into a state of quiescence and patients remain asymptomatic for years or even decades after anti-tumor therapies. Fibroblasts, which represent a predominant cell type in tumor microenvironment, play a pivotal role in determining the ultimate fate of tumor cells. This review recapitulates the pleiotropic roles of fibroblasts which are divided into normal, senescent, cancer-associated fibroblasts (CAFs) and circulation CAFs in tumor dormancy, relapse, metastasis and resistance to therapy to help the treatment of cancer metastasis.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/6a678bd01b204138936e41b34fc534cd Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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