Antimicrobial Susceptibility of Bacteria That Cause Bovine Respiratory Disease Complex in Alberta, Canada

Autor: R. Michele Anholt, Cassidy Klima, Nick Allan, Heather Matheson-Bird, Crystal Schatz, Praseeda Ajitkumar, Simon JG Otto, Delores Peters, Karin Schmid, Merle Olson, Tim McAllister, Brenda Ralston
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Frontiers in Veterinary Science, Vol 4 (2017)
Druh dokumentu: article
ISSN: 2297-1769
DOI: 10.3389/fvets.2017.00207
Popis: Bovine respiratory disease (BRD) is the most important illness of feedlot cattle. Disease management targets the associated bacterial pathogens, Mannheimia haemolytica, Mycoplasma bovis, Pasteurella multocida, Histophilus somni, and Trueperella pyogenes. We conducted a cross-sectional study to measure the frequencies of antimicrobial-resistant BRD pathogens using a collaborative network of veterinarians, industry, government, and a diagnostic laboratory. Seven private veterinary practices in southern Alberta collected samples from both living and dead BRD-affected animals at commercial feedlots. Susceptibility testing of 745 isolates showed that 100% of the M. haemolytica, M. bovis, P. multocida, and T. pyogenes isolates and 66.7% of the H. somni isolates were resistant to at least one antimicrobial class. Resistance to macrolide antimicrobials (90.2% of all isolates) was notable for their importance to beef production and human medicine. Multidrug resistance (MDR) was high in all target pathogens with 47.2% of the isolates resistant to four or five antimicrobial classes and 24.0% resistance to six to nine classes. We compared the MDR profiles of isolates from two feedlots serviced by different veterinary practices. Differences in the average number of resistant classes were found for M. haemolytica (p
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