| Autor: |
Hsin‐Ti Huang, Jin‐Long Huang, Po‐Lin Lin, Ying‐Hsiang Lee, Chien‐Yi Hsu, Fa‐Po Chung, Chia‐Te Liao, Wei‐Ru Chiou, Wen‐Yu Lin, Huai‐Wen Liang, Hung‐Yu Chang |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
ESC Heart Failure, Vol 9, Iss 6, Pp 3825-3835 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2055-5822 |
| DOI: |
10.1002/ehf2.14107 |
| Popis: |
Abstract Aims Sacubitril/valsartan (SAC/VAL) has been used in patients with heart failure and reduced ejection fraction (HFrEF), and cardiac resynchronization therapy (CRT) could benefit the HFrEF patients with wide QRS durations. This study aimed to evaluate the clinical impacts of SAC/VAL on reverse cardiac remodelling in CRT‐eligible and CRT‐ineligible HFrEF patients with different QRS durations. Methods and results The TAROT‐HF study was a multicentre, observational study enrolling patients who initiated SAC/VAL from 10 hospitals since 2017. Patients with baseline left ventricular ejection fraction (LVEF) ≤ 35% were classified into two groups: (i) Group 1: CRT‐eligible group, patients with left bundle branch block (LBBB) morphology plus QRS duration ≥130 ms or non‐LBBB morphology plus QRS duration ≥150 ms; and (ii) Group 2: CRT‐ineligible group. Propensity score matching was performed to adjust for confounders, and 1168 patients were analysed. Baseline characteristics were comparable between the two groups. The improvements in LVEF and left ventricular end‐systolic volume index (LVESVi) were more significant in Group 2 than in Group 1 after 1 year SAC/VAL treatment (LVEF: 8.4% ± 11.3% vs. 4.5% ± 8.1%, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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