Therapeutic Artemether-Lumefantrine Modulated Monosodium Glutamate-Related Adversity on Rats’ Kidney Histology and Antioxidant Response Bio-Indicators
| Autor: | A.C.C. Egbuonu, P.O. Alaebo, C.N. Uchukwu, D.D.C. Uwandu, I.M. Orji, J.C. Uzoechi, C.P. Nwuke |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Journal of Applied Sciences and Environmental Management, Vol 25, Iss 5 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2659-1502 2659-1499 |
| DOI: | 10.4314/jasem.v25i5.18 |
| Popis: | Co-intake-related interactive-synergistic influence of artemether-lumefantrine, AL and monosodium glutamate, MSG that separately mediated oxidative stress could be significant on the kidney actively involved in xenobiotic detoxification and elimination. Thus, influence of AL on rats’ kidney histomorphology and antioxidant bioindicators following MSG-challenge was assessed. For 7 days, thirty rats (n = 5) were respectively exposed to vehicle (distilled water), therapeutic AL (TAL), high AL (HAL), MSG, MSG plus TAL or MSG plus HAL. Significant (P0.05).Rats’ kidney photomicrographs (H&E × 400) revealed normal histo-architecture in control but varied degree of fibroplasias (TAL- ,HAL- and MSG plus TAL-fed) and necrosis with infiltrations (MSG plus HAL-and MSG-fed), rats. These demonstrated MSG-related adversity and significant modulation response of TAL, unlike HAL, on the rats’ kidney histology and studied antioxidant response bio-indicators. |
| Databáze: | Directory of Open Access Journals |
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