Elevated Serum Cystatin C and Decreased Cathepsin S/Cystatin C Ratio Are Associated with Severe Peripheral Arterial Disease and Polyvascular Involvement

Autor:	Előd Ernő Nagy, Attila Puskás, Piroska Kelemen, Katalin Makó, Zoltán Brassai, Jolán Hársfalvi, Attila Frigy
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	cystatin C cathepsin S atherosclerosis peripheral arterial disease ankle–brachial index polyvascular disease Medicine (General) R5-920
Zdroj:	Diagnostics, Vol 12, Iss 4, p 833 (2022)
Druh dokumentu:	article
ISSN:	2075-4418
DOI:	10.3390/diagnostics12040833
Popis:	Peripheral arterial disease (PAD) is frequently associated with atherosclerotic manifestations of the carotids and coronaries. Polyvascular involvement and low ankle–brachial index predict major cardiovascular events and high mortality. Cathepsin S (Cat S) promotes the inflammatory pathways of the arterial wall, while Cystatin C (Cys C) functions as its inhibitor; therefore, Cys C was proposed to be a biomarker of progression in PAD. In a single-center observational study, we investigated the correlations of serum Cys C and Cat S/Cys C ratio in a group of 90 PAD patients, predominantly with polyvascular involvement. Cys C and Cat S/Cys C were associated with ankle–brachial index (ABI) scores
Databáze:	Directory of Open Access Journals
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