The structure, biosynthesis, and biological roles of fetuin-A: A review

Autor: Endeshaw Chekol Abebe, Zelalem Tilahun Muche, Awigchew Behaile T/Mariam, Teklie Mengie Ayele, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Tadesse Asmamaw Dejenie, Misganaw Asmamaw Mengstie
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Druh dokumentu: article
ISSN: 2296-634X
DOI: 10.3389/fcell.2022.945287
Popis: Fetuin-A is a heterodimeric plasma glycoprotein containing an A-chain of 282 amino acids and a B-chain of 27 amino acid residues linked by a single inter-disulfide bond. It is predominantly expressed in embryonic cells and adult hepatocytes, and to a lesser extent in adipocytes and monocytes. Fetuin-A binds with a plethora of receptors and exhibits multifaceted physiological and pathological functions. It is involved in the regulation of calcium metabolism, osteogenesis, and the insulin signaling pathway. It also acts as an ectopic calcification inhibitor, protease inhibitor, inflammatory mediator, anti-inflammatory partner, atherogenic factor, and adipogenic factor, among other several moonlighting functions. Fetuin-A has also been demonstrated to play a crucial role in the pathogenesis of several disorders. This review mainly focuses on the structure, synthesis, and biological roles of fetuin-A. Information was gathered manually from various journals via electronic searches using PubMed, Google Scholar, HINARI, and Cochrane Library from inception to 2022. Studies written in English and cohort, case-control, cross-sectional, or experimental studies were considered in the review, otherwise excluded.
Databáze: Directory of Open Access Journals