| Autor: |
Vera Karamfilova, Iveta Nedeva, Tsvetan Gatev, Antoaneta Gateva, Yavor Assyov, Antonina Gerganova, Dobrin Popov, Tsvetelina Velikova, Zdravko Kamenov |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Pharmacia, Vol 70, Iss 4, Pp 1455-1461 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2603-557X |
| DOI: |
10.3897/pharmacia.70.e115795 |
| Popis: |
Background: Fetuin-A is a multifunctional liver-derived glycoprotein that is associated with insulin resistance and might play a role in the pathogenesis of prediabetes and type 2 diabetes (T2DM). Objective: This study evaluated the relationship of Fetuin-A with metabolic and vascular parameters in patients with prediabetes and T2DM. Materials and methods: total 120 obese patients were included. They were divided into three groups: group 1 – without carbohydrate disturbances, group 2 – with prediabetes and group 3 – with type 2 diabetes mellitus. Results: Higher Fetuin-A serum levels were observed in patients with prediabetes and T2DM compared to those with normoglycemia. Fetuin-A ≥821 mcg/ml increased the risk for T2DM 32-fold. Additionally, we found positive correlations between Fetuin-A, vibration perception threshold and toe-brachial index and a negative correlation with neuropathy disability score. Conclusion: Fetuin-A could be predictive for incidents of prediabetes and T2DM. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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