ER-positive and BRCA2-mutated breast cancer: a literature review

Autor: Pu-Chun Li, Yi-Fan Zhu, Wen-Ming Cao, Bei Li
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: European Journal of Medical Research, Vol 29, Iss 1, Pp 1-11 (2024)
Druh dokumentu: article
ISSN: 2047-783X
DOI: 10.1186/s40001-023-01618-1
Popis: Abstract BRCA2-mutated carriers have a high lifetime risk of breast cancer (BC), an early age of onset, and an increased risk of other cancers (including ovarian, pancreatic, and prostate cancer). Almost 70–80% of BRCA2-mutated BC are estrogen receptor (ER)-positive, which is a particular type of ER-positive BC that differs from sporadic ER-positive BC. This article reviews the clinicopathological features, treatment, and prognosis of ER-positive and BRCA2-mutated BC to provide a reference for clinical decision-making.
Databáze: Directory of Open Access Journals