RHO GTPase family in hepatocellular carcinoma

Autor: Tiantian Wang, Dean Rao, Chengpeng Yu, Jiaqi Sheng, Yiming Luo, Limin Xia, Wenjie Huang
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Experimental Hematology & Oncology, Vol 11, Iss 1, Pp 1-18 (2022)
Druh dokumentu: article
ISSN: 2162-3619
DOI: 10.1186/s40164-022-00344-4
Popis: Abstract RHO GTPases are a subfamily of the RAS superfamily of proteins, which are highly conserved in eukaryotic species and have important biological functions, including actin cytoskeleton reorganization, cell proliferation, cell polarity, and vesicular transport. Recent studies indicate that RHO GTPases participate in the proliferation, migration, invasion and metastasis of cancer, playing an essential role in the tumorigenesis and progression of hepatocellular carcinoma (HCC). This review first introduces the classification, structure, regulators and functions of RHO GTPases, then dissects its role in HCC, especially in migration and metastasis. Finally, we summarize inhibitors targeting RHO GTPases and highlight the issues that should be addressed to improve the potency of these inhibitors.
Databáze: Directory of Open Access Journals
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