| Autor: |
Malin Freidle, Hanna Johansson, Urban Ekman, Alexander V. Lebedev, Ellika Schalling, William H. Thompson, Per Svenningsson, Martin Lövdén, Alonso Abney, Franziska Albrecht, Hanna Steurer, Breiffni Leavy, Staffan Holmin, Maria Hagströmer, Erika Franzén |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-10 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2373-8057 |
| DOI: |
10.1038/s41531-021-00269-5 |
| Popis: |
Abstract Balance dysfunction is a disabling symptom in people with Parkinson’s disease (PD). Evidence suggests that exercise can improve balance performance and induce neuroplastic effects. We hypothesised that a 10-week balance intervention (HiBalance) would improve balance, other motor and cognitive symptoms, and alter task-evoked brain activity in people with PD. We performed a double-blind randomised controlled trial (RCT) where 95 participants with PD were randomised to either HiBalance (n = 48) or a control group (n = 47). We found no significant group by time effect on balance performance (b = 0.4 95% CI [−1, 1.9], p = 0.57) or on our secondary outcomes, including the measures of task-evoked brain activity. The findings of this well-powered, double-blind RCT contrast previous studies of the HiBalance programme but are congruent with other double-blind RCTs of physical exercise in PD. The divergent results raise important questions on how to optimise physical exercise interventions for people with PD. Preregistration clinicaltrials.gov: NCT03213873. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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