Triple threat to cancer: rationale for combining oncolytic viruses, MEK inhibitors, and immune checkpoint blockade

Autor:	Praveen K. Bommareddy, Samuel D. Rabkin, Howard L. Kaufman
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	immunotherapy mek inhibition melanoma oncolytic virus programmed cell death 1 (pd-1) Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	OncoImmunology, Vol 8, Iss 4 (2019)
Druh dokumentu:	article
ISSN:	2162-402X 2162402X
DOI:	10.1080/2162402X.2019.1571390
Popis:	In a recent edition of Science Translational Medicine, we identified an enhanced therapeutic activity when talimogene laherparepvec (T-VEC) was combined with MEK inhibition in murine melanoma tumor models. MEK inhibition increased viral replication independent of mutation status. Combination therapy increased PD-1/PD-L1 expression and PD-1 blockade further enhanced tumor regression. Further clinical development of this strategy for treating melanomas warranted.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/69f325c53a2d42cdb87bddc03ca9c6f3 Zobrazit plný text záznamu View record in DOAJ