Autor: |
Po-Hsiang Liao, Wei-Wen Kuo, Chia-Hua Kuo, Yu-Lan Yeh, Chia-Yao Shen, Ya-Hui Chen, Ray-Jade Chen, V. Vijaya Padma, Yi-Hsing Chen, Chih-Yang Huang |
Jazyk: |
angličtina |
Rok vydání: |
2016 |
Předmět: |
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Zdroj: |
Journal of Functional Foods, Vol 20, Iss , Pp 226-235 (2016) |
Druh dokumentu: |
article |
ISSN: |
1756-4646 |
DOI: |
10.1016/j.jff.2015.11.009 |
Popis: |
Probiotics are reported to provide protective health benefits against various disorders. In this study, we established a high-calorie diet animal model with a diet prepared by fortifying normal diet with soybean oil and condensed milk and the animals were supplemented with different dose of probiotic Lactobacillus reuteri GMNL-263(Lr263) for 8 weeks to investigate the protective function. We measured the lipid levels in plasma, liver and faecal; heart weight, function and collagen accumulation and biochemical markers of cardiac disease. Lr263 reversed high-calorie diet-induced cardiac weight gain, systolic malfunction and prevented heart inflammation by decreasing inflammation proteins NF-κB and COX-2. Moreover, Lr263 reduced cardiac eccentric hypertrophy and the levels of cardiac fibrosis markers CTGF and SP1 in high-calorie diet-fed rat hearts. Thus, Lr263 is considered as a functional food that provides anti-inflammatory, anti-hypertrophic, anti-fibrotic functions and identified specific biologic effects in reducing the characteristics of the high-calorie diet-induced progression to heart failure. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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