Autor: |
Mi-Yoon Chang, Yong-Hee Rhee, Sang-Hoon Yi, Su-Jae Lee, Rae-Kwon Kim, Hyongbum Kim, Chang-Hwan Park, Sang-Hun Lee |
Jazyk: |
angličtina |
Rok vydání: |
2014 |
Předmět: |
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Zdroj: |
Stem Cell Reports, Vol 3, Iss 2, Pp 353-364 (2014) |
Druh dokumentu: |
article |
ISSN: |
2213-6711 |
DOI: |
10.1016/j.stemcr.2014.06.013 |
Popis: |
We here report that doxycycline, an antibacterial agent, exerts dramatic effects on human embryonic stem and induced pluripotent stem cells (hESC/iPSCs) survival and self-renewal. The survival-promoting effect was also manifest in cultures of neural stem cells (NSCs) derived from hESC/iPSCs. These doxycycline effects are not associated with its antibacterial action, but mediated by direct activation of a PI3K-AKT intracellular signal. These findings indicate doxycycline as a useful supplement for stem cell cultures, facilitating their growth and maintenance. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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