Doxycycline Enhances Survival and Self-Renewal of Human Pluripotent Stem Cells

Autor: Mi-Yoon Chang, Yong-Hee Rhee, Sang-Hoon Yi, Su-Jae Lee, Rae-Kwon Kim, Hyongbum Kim, Chang-Hwan Park, Sang-Hun Lee
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Stem Cell Reports, Vol 3, Iss 2, Pp 353-364 (2014)
Druh dokumentu: article
ISSN: 2213-6711
DOI: 10.1016/j.stemcr.2014.06.013
Popis: We here report that doxycycline, an antibacterial agent, exerts dramatic effects on human embryonic stem and induced pluripotent stem cells (hESC/iPSCs) survival and self-renewal. The survival-promoting effect was also manifest in cultures of neural stem cells (NSCs) derived from hESC/iPSCs. These doxycycline effects are not associated with its antibacterial action, but mediated by direct activation of a PI3K-AKT intracellular signal. These findings indicate doxycycline as a useful supplement for stem cell cultures, facilitating their growth and maintenance.
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