| Autor: |
Matthieu P.M.H. Benoit, Ana B. Asenjo, Mohammadjavad Paydar, Sabin Dhakal, Benjamin H. Kwok, Hernando Sosa |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-021-23581-3 |
| Popis: |
KIF14 is a mitotic kinesin whose malfunction is associated with cerebral and renal developmental defects and several cancers. Here the authors use cryoEM to determine 20 structures of KIF14 constructs bound to microtubules in the presence of different nucleotide analogues and provide the structural basis for a coordinated chemo-mechanical kinesin translocation model. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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