| Autor: |
Won Hoon Choi, Stefanie A. H. de Poot, Jung Hoon Lee, Ji Hyeon Kim, Dong Hoon Han, Yun Kyung Kim, Daniel Finley, Min Jae Lee |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/ncomms10963 |
| Popis: |
The proteasome plays a key role in proteostasis by mediating the degradation of ubiquitinated substrates. Here the authors show that an open-gate mutant of the proteasome is hyperactive towards a subset of substrates and can effectively delay the accumulation of toxic protein aggregates. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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