Biochemical, Histopathologic, and Genotoxic Effects of Ethanol Extract of Salvia hypargeia (Fisch. & Mey.) on Incisional and Excisional Wounded Diabetic Rats

Autor: Yusuf Ozay, Sevda Guzel, Ebru Gokalp Ozkorkmaz, Meltem Kumas, Cosar Uzun, Zuhal Yıldırım, Ayla Celik, Yusuf Camlıca, Onder Yumrutas, Gizem Guler, Nurten Erdal, Bahar Tasdelen, Havva Didem Celikcan, Ahmet Kahraman
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Investigative Surgery, Vol 34, Iss 1, Pp 7-19 (2021)
Druh dokumentu: article
ISSN: 0894-1939
1521-0553
08941939
28548930
DOI: 10.1080/08941939.2019.1590483
Popis: Purpose: Nonhealing wounds are a serious problem of diabetic patients. Salvia species are traditionally used for the treatment of wounds. The aim of the study was to investigate the effects of ointment prepared with ethanol extract obtained from the aerial parts of Salvia hypargeia, an endemic plant from Turkey, on diabetic rat incisional and excisional skin wounds. Materials and Methods: Male Wistar albino rats (n: 60) were divided into five groups. Diabetes was induced and two concentrations (0.5% and 1%) of the extract were used for ointments and applied on wounds for 7 and 14 days. Fito cream was chosen as a reference drug. Results: In excisional wounds, healing ratios of 0.5% (63.4% and 99.3%) and 1% (65.5% and 99.9%) S. hypargeia groups were higher compared to control (35.9% and 75.1%), and in incisional wounds, healing ratios of 0.5% (78.1% and 98.5%) and 1% (84.4% and 99.4%) S. hypargeia groups were higher compared to control (30.5% and 72.9%) (p
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