Assessment of Kidney Function After Transcatheter Aortic Valve Replacement

Autor: Orit Kliuk-Ben Bassat, Sapir Sadon, Svetlana Sirota, Arie Steinvil, Maayan Konigstein, Amir Halkin, Samuel Bazan, Ayelet Grupper, Shmuel Banai, Ariel Finkelstein, Yaron Arbel
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Canadian Journal of Kidney Health and Disease, Vol 8 (2021)
Druh dokumentu: article
ISSN: 2054-3581
20543581
DOI: 10.1177/20543581211018029
Popis: Background: Transcatheter aortic valve replacement (TAVR), although associated with an increased risk for acute kidney injury (AKI), may also result in improvement in renal function. Objective: The aim of this study is to evaluate the magnitude of kidney function improvement (KFI) after TAVR and to assess its significance on long-term mortality. Design: This is a prospective single center study. Setting: The study was conducted in cardiology department, interventional unit, in a tertiary hospital. Patients: The cohort included 1321 patients who underwent TAVR. Measurements: Serum creatinine level was measured at baseline, before the procedure, and over the next 7 days or until discharge. Methods: Kidney function improvement was defined as the mirror image of AKI, a reduction in pre-procedural to post-procedural minimal creatinine of more than 0.3 mg/dL, or a ratio of post-procedural minimal creatinine to pre-procedural creatinine of less than 0.66, up to 7 days after the procedure. Patients were categorized and compared for clinical endpoints according to post-procedural renal function change into 3 groups: KFI, AKI, or preserved kidney function (PKF). The primary endpoint was long-term all-cause mortality. Results: The incidence of KFI was 5%. In 55 out of 66 patients patients, the improvement in kidney function was minor and of unclear clinical significance. Acute kidney injury occurred in 19.1%. Estimated glomerular filtration rate (eGFR)
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