Phenotypic and Genotypic Adaptations in Pseudomonas aeruginosa Biofilms following Long-Term Exposure to an Alginate Oligomer Therapy

Autor: Juliette L. Oakley, Rebecca Weiser, Lydia C. Powell, Julian Forton, Eshwar Mahenthiralingam, Philip D. Rye, Katja E. Hill, David W. Thomas, Manon F. Pritchard
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: mSphere, Vol 6, Iss 1 (2021)
Druh dokumentu: article
ISSN: 2379-5042
DOI: 10.1128/mSphere.01216-20
Popis: The emergence of multidrug-resistant (MDR) pathogens within biofilms in the cystic fibrosis lung results in increased morbidity. An inhalation therapy derived from alginate, OligoG CF-5/20, is currently in clinical trials for cystic fibrosis patients.
Databáze: Directory of Open Access Journals