Sensing the squeeze: nuclear mechanotransduction in health and disease

Autor:	Luv Kishore Srivastava, Allen J. Ehrlicher
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Chromatin lamin A/C LINC complex mechanotransduction nuclear deformation Genetics QH426-470 Cytology QH573-671
Zdroj:	Nucleus, Vol 15, Iss 1 (2024)
Druh dokumentu:	article
ISSN:	19491034 1949-1042 1949-1034
DOI:	10.1080/19491034.2024.2374854
Popis:	The nucleus not only is a repository for DNA but also a center of cellular and nuclear mechanotransduction. From nuclear deformation to the interplay between mechanosensing components and genetic control, the nucleus is poised at the nexus of mechanical forces and cellular function. Understanding the stresses acting on the nucleus, its mechanical properties, and their effects on gene expression is therefore crucial to appreciate its mechanosensitive function. In this review, we examine many elements of nuclear mechanotransduction, and discuss the repercussions on the health of cells and states of illness. By describing the processes that underlie nuclear mechanosensation and analyzing its effects on gene regulation, the review endeavors to open new avenues for studying nuclear mechanics in physiology and diseases.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/69b0f1644f2b4919a922f43fa0f9bbef Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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