Polymorphisms in the Promoter Region of the Chinese Bovine Gene

Autor: M. J. Li, M. Liu, D. Liu, X. Y. Lan, C. Z. Lei, D. Y. Yang, H. Chen
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Asian-Australasian Journal of Animal Sciences, Vol 26, Iss 4, Pp 483-487 (2013)
Druh dokumentu: article
ISSN: 1011-2367
1976-5517
DOI: 10.5713/ajas.2012.12554
Popis: The peroxisome proliferator-activated receptor gamma coactivator-1 alpha protein, encoded by the PPARGC1A gene, plays an important role in energy homeostasis. The genetic variations within the PPARGC1A gene promoter region were scanned in 808 Chinese native bovines belonging to three cattle breeds and yaks. A total of 6 SNPs and one 4 bp insertion variation in the promoter region of the bovine PPARGC1A gene were identified: SNP -259 T>A, -301_-298insCTTT, -915 A>G, -1175 T>G, -1590 C>T, -1665 C>T and -1690 G>A, which are in the binding sites of some important transcription factors: sex-determining region Y (SRY), myeloid-specific zinc finger-1 (MZF-1) and octamer factor 1(Oct-1). It is expected that these polymorphisms may regulate PPARGC1A gene transcription and might have consequences at a regulatory level.
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