The Brain at High Altitude: From Molecular Signaling to Cognitive Performance

Autor:	Mostafa A. Aboouf, Markus Thiersch, Jorge Soliz, Max Gassmann, Edith M. Schneider Gasser
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	hypoxia HIF EPO neurogenesis synaptogenesis carotid body Biology (General) QH301-705.5 Chemistry QD1-999
Zdroj:	International Journal of Molecular Sciences, Vol 24, Iss 12, p 10179 (2023)
Druh dokumentu:	article
ISSN:	1422-0067 1661-6596
DOI:	10.3390/ijms241210179
Popis:	The brain requires over one-fifth of the total body oxygen demand for normal functioning. At high altitude (HA), the lower atmospheric oxygen pressure inevitably challenges the brain, affecting voluntary spatial attention, cognitive processing, and attention speed after short-term, long-term, or lifespan exposure. Molecular responses to HA are controlled mainly by hypoxia-inducible factors. This review aims to summarize the cellular, metabolic, and functional alterations in the brain at HA with a focus on the role of hypoxia-inducible factors in controlling the hypoxic ventilatory response, neuronal survival, metabolism, neurogenesis, synaptogenesis, and plasticity.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/69a10c32f82f42919686967b5b080c1a Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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