| Autor: |
Hui Zhang, Li-Wu Fu, Xiao-Kun Wang, Xiao-Qin Zhao, Yan-Jun Mi, Fang Wang, Li-Sheng Zheng, Yong-Ju Liang, Hu-Biao Chen, Jian-Ye Zhang |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Molecules, Vol 16, Iss 4, Pp 3222-3231 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
1420-3049 |
| DOI: |
10.3390/molecules16043222 |
| Popis: |
In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed. Its anticancer activity in vitro against lung cancer A549 cells was also investigated and the IC50 values were 34.04 ± 3.99 μM. Furthermore, Euphorbia factor L3 could induce apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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