Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum

Autor: Valeriu Bortnov, Marco Tonelli, Woonghee Lee, Ziqing Lin, Douglas S. Annis, Omar N. Demerdash, Alex Bateman, Julie C. Mitchell, Ying Ge, John L. Markley, Deane F. Mosher
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-13577-5
Popis: Myeloid-derived growth factor (MYDGF) is an endoplasmic reticulum protein of therapeutic interest because it promotes tissue repair in a murine model of myocardial infarction. Here the authors present the NMR structure of human MYDGF and attribute function to a set of residues conserved in MYDGFs but not the vanin base domain, which has a similar fold.
Databáze: Directory of Open Access Journals