The potential role of minimal/molecular residual disease in colorectal cancer: curative surgery, radiotherapy and beyond

Autor: Meiyi Xu, Tianhao Shi, Ruilian Xu, Gong Chen, Wan He
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of the National Cancer Center, Vol 3, Iss 3, Pp 203-210 (2023)
Druh dokumentu: article
ISSN: 2667-0054
DOI: 10.1016/j.jncc.2023.05.005
Popis: Detection of minimal/molecular residual disease (MRD) based on ctDNA assay develops from hematological malignancies to solid tumors. Generally, there are two mainstream assays in MRD testing technology: tumor-informed and tumor-agnostic. For colorectal cancer (CRC), MRD is used not only to monitor recurrence and predict prognosis, but also to help in clinical decision making and assessment of clinical efficacy in the settings of curative surgery, radiotherapy, chemotherapy and surveillance. Accumulated clinical trials are exploring roles of MRD in early or advanced stages of CRC. Here, we give an overview of how MRD is and will be used in CRC.
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