| Autor: |
Ahmed Belkouch, Said Jidane, Naoufal Chouaib, Anass Elbouti, Tahir Nebhani, Rachid Sirbou, Hicham Bakkali, Lahcen Belyamani |
| Jazyk: |
English<br />French |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
The Pan African Medical Journal, Vol 21, Iss 37 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1937-8688 |
| DOI: |
10.11604/pamj.2015.21.37.6491 |
| Popis: |
INTRODUCTION: thrombolysis has radically changed the prognosis of acute ischemic stroke. Tenecteplase is a modified form of rt-PA with greater specificity for fibrin and a longer half-life. We report the experience of a Moroccan tertiary hospital in thrombolysis using Tenecteplase. METHODS: we conducted an open prospective study of all patients who were treated with Tenecteplase for anacute ischemic stroke admitted to our emergency department. Tenecteplase was administered intravenously at a dose of 0.4 mg/kg single bolus. The primary outcome measure was the proportion of patients achieving significant early neurological recovery defined as an improvement of 4 or more points on the NIHSS score at 24h. RESULTS: 13 patients had been treated by intravenous thrombolysis. 31% were women. Mean age was 63 years old. The mean NIHSS score at admission was 14.3 and 24h after was at 9.1. The right middle cerebral arterywas involved in 69% of cases. The carotid atherosclerosis was predominant 63.3% and the cardio embolic etiology 27%. The mean time to the first medical contact after the onset of symptoms was 3h 30 min. One patient presented a capsulo-lenticular hematoma of 5 mm3 in the same side of the ischemic stroke. CONCLUSION: tenecteplase is a more interesting thrombolytic than alteplase, it seems to be more suitable for thrombolysis in our center. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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